Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P
Physiological targets and you may pharmacology regarding curcumin
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin ‘s the major element of the new red-colored dye out of turmeric, a keen Indian spice which is extracted from the rhizome of your own warm plant Curcuma longa, and that is one of the Zingiberaceae family members. Inside part, we talk about the pharmacological situations off curcumin and you may speak about the fresh unit basics for those factors. We upcoming comment new shown and prospective systematic uses off curcumin. Curcumin is known over the years because a restorative broker, but the process from action are in depth. New pharmacological aftereffects of curcumin seem to be caused by a great synergism away from networks from poor biochemical interactions which have several physiological objectives in interconnected signaling routes. These objectives were minerals including cyclooxygenase, lipoxygenase and proteins kinases, and you will transcription circumstances such as for example NF-?B, STAT and you may Nrf2. Modulation ones molecules has an effect on downstream affectors that make this new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you can antimicrobial things of curcumin. These outcomes was tested for the scientific products out of curcumin getting serious pain and you may inflammatory illness, disease, Alzheimer problem, aerobic ailment, and you will diabetic issues. The fresh samples have tried variable dosage of curcuminwith some other wavelengths and you will years, for the standard achievement you to large dosages of curcumin during the quantity of grams have to receive healing consequences. Read more
Curcumin: Synthesis, Emerging Role for the Serious pain Management and Fitness Ramifications
Book Part Samples of plant-derived pharmaceuticals which have get to be the attract from continuous and great browse and you can invention focus have, thus far, been slightly scarce. Once years, the last 20 years had been described as good 100-bend rise in exactly how many medical stuff typed annually one to try of advantages towards the use of curcumin when you look at the biomedicine. Read more
Design, synthesis and you may physical issues from curcumin prodrugs
Publication ChapterAsma El-Magboub AsianMelodies dato ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has some possible pharmacological effects that will has therapeutic software in lot of problem claims, given that chatted about in detail in the previous part. not, the possibility systematic effectiveness regarding curcumin is bound by its physicochemical properties of worst liquid solubility and you may instability, and that trigger low bioavailability. Prodrugs of curcumin offer an easy way to upgrade of the biopharmaceutical and you may pharmacokinetic services, and will ensure it is exploitation of pharmacological effects of curcumin. In this section, we very first opinion this new physicochemical and you may pharmacokinetics from curcumin. We after that describe the appearance of curcumin prodrugs which have increased drinking water solubility and increased chemical substances stability which are often converted to totally free curcumin through to bioactivation inside the vivo. I focus on previous achievements in this area, that have a focus on the structure, synthesis and you may analysis of prodrugs centered on promoieties and amino acids, efas, nucleic acids, dicarboxylic acids, and you can polymeric content such as for instance hyaluronic acidic and you may polyethylene glycol. So it section comes with the reason for optimization of physicochemical and you can biopharmaceutical properties in addition to physiological situations regarding curcumin prodrugs, to the mission using of those curcumin derivatives from inside the systematic software. Find out more